Abstract
Chronic kidney disease (CKD) is an important factor of loss of quality of life and high rates of morbidity and mortality, where cardiovascular diseases are the main responsible for this poorer prognosis. It is verified that CKD is associated with high inflammatory levels in the body, or that it seems to contribute to these cardiovascular events. Thus, CKD is characterized by a high inflammatory profile, as well as possibly a large imbalance in adipokines due to changes in body composition. Thus, adiponectin and leptin emerge as possible inflammatory modulators, although their popular effects are not completely elucidated. On the other hand, it is proven that physical exercise can be a great tool in the treatment of CKD and in the modulation of biomarkers, stimulating in an anti-inflammatory way and promoting an adjustment in the main causes of morbidity and mortality in this population. Thus, this review seeks to elucidate the role of exercise as a modulator of inflammation and the leptin/adiponectin relationship in order to contribute to the better quality of life of this population, in addition to demonstrating the important role that exercise can exert in modulation of these biomarkers, aiming to minimize the cardiovascular effects that these biomarkers exert on this population.
Keywords
Leptin, Adiponectin, Chronic Kidney Disease, Physical Exercise,References
- Alix, P.M., Guebre-Egziabher, F., Soulage, C.O. (2014). Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. Biochimie, 105, 12-21.
- Alizadeh, S., Ahmadi, M., Ghorbani Nejad, B., Djazayeri, A., Shab-Bidar, S. (2018). Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies. International Journal of Clinical Practice, 72(8).
- Bigley, A.B., Rezvani, K., Pistillo, M., Reed, J., Agha, N., Kunz, H., O'Connor, D.P., Sekine, T., Bollard, C.M., Simpson, R.J. (2015). Acute exercise preferentially redeploys NK-cells with a highly differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: impact of latent cytomegalovirus infection and catecholamine sensitivity. Brain, Behavior, and Immunity, 49, 59-65.
- Carballo, M.C.S., Pinto, L.C.S., Brito, M.V.H. (2020) The role of adiponectin in ischemia-reperfusion syndrome: a literature review. Einstein (Sao Paulo), 18, eRW5160.
- Carvalho, M.H.C.de, Colaço, A.L., Fortes, Z.B. (2006) Citocinas, disfunção endotelial e resistência à insulina. Arquivos Brasileiros de Endocrinologia & Metabologia. 50 (2), 304-12.
- Chen, J., Muntner, P., Hamm, L.L., Jones, D.W., Batuman, V., Fonseca, V., Whelton, P.K., He, J. (2004) The metabolic syndrome and chronic kidney disease in U.S. adults. Annals of Internal Medicine. 140(3), 167-74.
- Choi, H.M., Doss, H.M., Kim, K.S. (2020) Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. International Journal of Molecular Sciences, 21(4), 1219.
- Cocate, P.G., Domingues, S.F., Natali, A.J. (2011). Concentrações sanguíneas de adiponectina e exercício físico: associações com a sensibilidade insulínica. Revista Brasileira de Ciências do Esporte, 33, 787-798.
- Correia, M.L.G., Rahmouni, K. (2006) Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes, Obesity and Metabolism. 8(6), 603-10.
- Czaja-Stolc, S., Potrykus, M., Stankiewicz, M., Kaska, Ł., Małgorzewicz, S. (2022) Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease. Nutrients, 14(7), 1457.
- Ding, N., Liu, B., Song, J., Bao, S., Zhen, J., Lv, Z., Wang, R. (2016) Leptin promotes endothelial dysfunction in chronic kidney disease through AKT/GSK3β and β-catenin signals. Biochemical and Biophysical Research Communications, 480(4), 544-551.
- dos Santos Pinho, K.H., De Paiva, M.J., de Carvalho Oliveira, R.A. (2022). Leptina e adiponectina: papel dos hormônios nos processos metabólicos e impactos na sua desregulação. Research, Society and Development, 11(2), e34711225144-e34711225144.
- França, M., Souza, S., Marques, N. (2017) Benefícios da prática de exercício físico em pacientes com síndrome metabólica. DêCiência em Foco, 1(1), 30-47.
- Golembiewska, E., Safranow, K., Ciechanowski, K., Bober, J., Bogacka, A., Stepniewska, J. (2013) Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients. Acta Biochimica Polonica. 60(4) 617-21.
- Greffin, S., André, M.B., Matos, J.P.S., Kang, H.C., Jorge, A.J.L., Rosa, M.L.G., Lugon, J.R. (2017) Chronic kidney disease and metabolic syndrome as risk factors for cardiovascular disease in a primary care program. Jornal Brasileiro de Nefrologia, 39(3), 246-252.
- Gunta, S.S., Mak, R.H. (2013) Ghrelin and leptin pathophysiology in chronic kidney disease. Pediatric Nephrology, 28(4), 611-6.
- Harlan, S.M., Rahmouni, K. (2013). PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin. Molecular metabolism, 2(2), 69-73.
- Kamimura, M.A., Canziani, M.E.F., Sanches, F.R., Velludo, C.M., Carrero, J.J., Bazanelli, A.P., Draibe, S.A. and Cuppari, L., (2012). Variações nos níveis de adiponectina nos pacientes com doença renal crônica: um estudo prospectivo de 12 meses. Brazilian Journal of Nephrology, 34, 259-265.
- Katsiki, N., Mikhailidis, D.P., Banach, M. (2018) Leptin, cardiovascular diseases and type 2 diabetes mellitus. Acta Pharmacologica Sinica, 39(7), 1176-88.
- Kaynar, K., Kural, B.V., Ulusoy, S., Cansiz, M., Akcan, B., Misir, N., Yaman, S., Kaya, N. (2014) Is there any interaction of resistin and adiponectin levels with protein-energy wasting among patients with chronic kidney disease. Hemodialysis International, 18(1), 153-62.
- Kim, H.Y., Bae, E.H., Ma, S.K., Chae, D.W., Choi, K.H., Kim, Y.S., Hwang, Y.H., Ahn, C., Kim, S.W. (2016). Association of serum adiponectin level with albuminuria in chronic kidney disease patients. Clinical and Experimental Nephrology, 20(3), 443-449.
- Kim, M.J., Park, K.Y., Lee, M.K., Jin. T., Seong, J.S. (2016). Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes. PLoS One, 11(8), e0161247-7.
- Korczynska, J., Czumaj, A., Chmielewski, M., Swierczynski, J., Sledzinski, T. (2021) The Causes and Potential Injurious Effects of Elevated Serum Leptin Levels in Chronic Kidney Disease Patients. International Journal of Molecular Sciences, 22(9), 4685.
- Krause, M., Milne, K., Hawke, T. (2019) Adiponectin-Consideration for its Role in Skeletal Muscle Health. International Journal of Molecular Sciences, 20(7), 1528.
- Li, J., Shen, X. (2019) Oxidative stress and adipokine levels were significantly correlated in diabetic patients with hyperglycemic crises. Diabetology & Metabolic Syndrome, 11(1), 13.
- Magherini, F., Fiaschi, T., Marzocchini, R., Mannelli, M., Gamberi, T., Modesti, P.A., Modesti, A. (2019) Oxidative stress in exercise training: the involvement of inflammation and peripheral signals. Free Radical Research, 53(11-12):1155-1165.
- Martins, M.d.C., Faleiro, L.L, Fonseca, A. (2012) Relação entre a leptina, a massa corporal e a síndrome metabólica numa amostra da população adulta [Relationship between leptin and body mass and metabolic syndrome in an adult population]. Revista Portuguesa de Cardiologia, 31(11), 711-9.
- Mihai, S., Codrici, E., Popescu, I.D., Enciu, A.M., Albulescu, L., Necula, L.G., Mambet, C., Anton, G., Tanase, C. (2018) Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome. Journal of Immunology Research, 6, 1-16.
- Myers, M.G., Cowley, M.A., Münzberg, H. (2008). Mechanisms of Leptin Action and Leptin Resistance. Annual Review of Physiology, 70(1), 537-56.
- Navaneethan, S.D., Kirwan, J.P., Remer, E.M., Schneider, E., Addeman, B., Arrigain, S., Horwitz, E., Fink, J.C., Lash, J.P., McKenzie, C.A., Rahman, M., Rao, P.S., Schold, J.D., Shafi, T., Taliercio, J.J., Townsend, R.R., Feldman, H.I. CRIC Study Investigators. (2021). Adiposity, Physical Function, and Their Associations with Insulin Resistance, Inflammation, and Adipokines in CKD. American Journal of Kidney Diseases, 77(1), 44-55.
- Nieman, D.C., Wentz, L.M. (2019) The compelling link between physical activity and the body's defense system. Journal of Sport and Health Science, 8(3), 201-217.
- Oliveira, R.F., Daniele, T.M.D.C., Façanha, C.F.S., Forti, A.C.E., Bruin, P.F.C., Bruin, V.M.S. (2018) Adiponectin levels and sleep deprivation in patients with endocrine metabolic disorders. Revista da Associação Médica Brasileira, 64(12), 1122-8.
- Parida, S., Siddharth, S., Sharma, D. (2019). Adiponectin, Obesity, and Cancer: Clash of the Bigwigs in Health and Disease. International Journal of Molecular Sciences, 20(10), 2519.
- Pilon, L.D.C. (2018). Análise da Influência do Exercício Físico nos Níveis Circulante de Leptina: Uma Revisão Bibliográfica, Universidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claro. (2018) 0-45.
- Prado, W.L.D, Lofrano, M.C., Oyama, L.M., Dâmaso, A.R. (2009) Obesidade e adipocinas inflamatórias: implicações práticas para a prescrição de exercícios. Revista Brasileira de Medicina do Esporte. 15(5), 378-83.
- Przybyciński, J., Dziedziejko, V., Puchałowicz, K., Domański, L., Pawlik, A. (2020) Adiponectin in Chronic Kidney Disease. International Journal of Molecular Sciences, 21(24), 9375.
- Rapa, S.F., Di Iorio, B.R., Campiglia, P., Heidland, A., Marzocco, S. (2019) Inflammation and Oxidative Stress in Chronic Kidney Disease-Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. International Journal of Molecular Sciences. 21(1), 263.
- Rhee, C.M., Nguyen, D.V., Moradi, H., Brunelli, S.M., Dukkipati, R., Jing, J., Nakata, T., Kovesdy, C.P., Brent, G.A., Kalantar-Zadeh, K. (2015) Association of Adiponectin With Body Composition and Mortality in Hemodialysis Patients. American Journal of Kidney Diseases, 66(2), 313-21.
- Romero, C.E.M., Zanesco, A. (2006). O papel dos hormônios leptina e grelina na gênese da obesidade. Revista de Nutrição. 19(1), 85-91.
- Scheffer, D.L., Latini, A. (2020). Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1866(10), 165823.
- Sellami, M., Gasmi, M., Denham, J., Hayes, L.D., Stratton, D., Padulo, J., Bragazzi, N. (2018). Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?. Frontiers in Immunology, 9, 2187.
- Senna, S.M., Torres, M.K., Lopes, D.A., Alheiros-Lira, M.C., de Moura, D.B., Pereira, V.R., de Aguiar F.C., Ferraz, J.C., Leandro, C.G. (2016). Moderate physical training attenuates perinatal low-protein-induced spleen lymphocyte apoptosis in endotoxemic adult offspring rats. European Journal of Nutrition, 55(3), 1113-22.
- Sharma, K., Ramachandrarao, S., Qiu, G., Usui, H.K., Zhu, Y., Dunn, S.R., Ouedraogo, R., Hough, K., McCue, P., Chan, L., Falkner, B., Goldstein, B.J. (2008). Adiponectin regulates albuminuria and podocyte function in mice. Journal of Clinical Investigation, 118(5), 1645-56.
- Silva Junior, G.B., Bentes, A.C., Daher, E.F., Matos, S.M. (2017). Obesity and kidney disease. Jornal Brasileiro de Nefrologia, 39(1), 65-69.
- Silva, G.M.D., Sandes, M.D.O., Vasconcelos-Filho, F.S.L., Rocha, D.S., Rocha-e-Silva, R.C.D., Silva, C.A.D., Chaves, E.C.B. and Brito, I.R., (2020). Responses of plasma adipokines to high intensity interval training: systematic review. Revista Brasileira de Medicina do Esporte, 26(3), 262-266.
- Simpson, R.J., Kunz, H., Agha, N., Graff, R. (2015). Exercise and the regulation of immune functions. Progress in Molecular Biology and Translational Science, 135, 355-379.
- Song, S.H., Oh, T.R., Choi, H.S., Kim, C.S., Ma, S.K., Oh, K.H., Ahn, C., Kim, S.W., Bae, E.H. (2020). High serum adiponectin as a biomarker of renal dysfunction: Results from the KNOW-CKD study. Scientific Reports, 10(1), 5598.
- Stępień, M., Wlazeł, R.N., Paradowski, M., Banach, M., Rysz, M., Misztal, M., Rysz, J. (2012). Serum concentrations of adiponectin, leptin, resistin, ghrelin and insulin and their association with obesity indices in obese normo- and hypertensive patients - pilot study. Archives of Medical Science, 8(3), 431-6.
- Tan, Q., Li, Y., Guo, Y. (2021) Exercício Físico Melhora as Funções das Células Progenitoras Endoteliais em Pacientes com Síndrome Metabólica. Arquivos Brasileiros de Cardiologia, 117(1), 108-17.
- Terra, R., Silva, S.A.G.D., Pinto, V.S., & Dutra, P.M.L. (2012). Efeito do exercício no sistema imune: resposta, adaptação e sinalização celular. Revista brasileira de medicina do esporte, 18(3), 208-214.
- Viana, J.L., Kosmadakis, G.C., Watson, E.L., Bevington, A., Feehally, J., Bishop, N.C., Smith, A.C. (2014). Evidence for anti-inflammatory effects of exercise in CKD. 25(9), 2121-30.
- Villanego, F., Naranjo, J., Vigara, L.A., Cazorla, J.M., Montero, M.E., García, T., Torrado, J., Mazuecos, A. (2020) Impacto del ejercicio físico en pacientes con enfermedad renal crónica: revisión sistemática y metaanálisis. Nefrología. 40(3), 237-252.
- Wang, J., Liu, S., Li, G., Xiao, J. (2020). Exercise Regulates the Immune System. Advances in Experimental Medicine and Biology, 1228, 395-409.
- Wilkinson, T.J., Shur, N.F., Smith, A.C. (2016). “Exercise as medicine” in chronic kidney disease. Scandinavian journal of medicine & science in sports, 26(8), 985-988.
- Wilund, K.R., Viana, J.L., Perez, L.M. (2020). A Critical Review of Exercise Training in Hemodialysis Patients: Personalized Activity Prescriptions Are Needed. Exercise And Sport Sciences Reviews, 48(1), 28-39.
- Wolf, G., Hamann, A., Han, D. C., Helmchen, U., Thaiss, F., Ziyadeh, F. N., & Stahl, R. A. (1999). Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells: potential role in glomerulosclerosis. Kidney international, 56(3), 860-872.
- Wu, L., Liu, Y., Wu, L., Yang, J., Jiang, T., Li, M. (2022). Effects of exercise on markers of inflammation and indicators of nutrition in patients with chronic kidney disease: a systematic review and meta-analysis. International Urology and Nephrology, 54(4), 815-826.
- Zelle, D.M., Corpeleijn, E., Stolk, R.P., de Greef, M.H., Gans, R.O., van der Heide, J.J., Navis, G., Bakker, S.J. (2011). Low physical activity and risk of cardiovascular and all-cause mortality in renal transplant recipients. Clinical Journal of the American Society of Nephrology, 6(4), 898-905.